A thin film measuring 4 centimeters square and 6 microns thick can be attached to the surface of the brain's functional area outside the dura mater to collect brain signals. On April 26th, the reporter saw at the Beijing Institute of Neuroscience and Brain like Research (hereinafter referred to as "Beihang Institute") that due to the use of micro nano technology, the flexible thin film electrode brain computer interface product undergoing clinical trials is thinner and less sensitive than the traditional silicone electrode model. At the Sanbo Brain Hospital of Capital Medical University, with the signal decoding support of brain computer interface technology, the neural regulation that previously required continuous intervention has been enhanced with real-time monitoring and even prediction functions, enabling immediate intervention when there is no harm or abnormality. With the approval and launch of the world's first invasive brain computer interface medical device in China, the driving force for the industrialization of brain computer interface technology is even stronger, including lower damage, lower energy consumption, higher precision, and wider application range. Technological innovation is constantly breaking through, and many technical pain points and application bottlenecks of brain computer interfaces are being solved one by one, promoting the continuous maturity and growth of the industry as a new economic growth point. Innovative technology and process make it more compatible. "Participants in a clinical trial abroad removed and discarded a brain computer interface product after 6 months of implantation, reportedly causing severe scalp discomfort due to its large size. ”Zhang Lei, director of the Instrumentation Center at Beijing Institute of Brain Science and Technology, told Science and Technology Daily reporters that clinical applications have different requirements for products than laboratory validation. When designing products, the user's experience should be considered, and the lighter, smaller, and less sensitive the product, the better. The classic signal path of brain computer interface is to transmit EEG signals to a signal collector fixed on the skull through electrodes, wirelessly transmit them into an external device the size of a mobile phone, and then summarize them on a computing platform for decoding. Finally, the obtained instructions are sent to the device terminal to achieve control of limbs and other aspects. The signal host needs to be fixed on the skull. The aforementioned foreign product is 12 millimeters thick, exceeding the height of the skull groove. The patient was forced to interrupt the test due to strong discomfort. The 'Beinao-1' host we developed is only 6 millimeters thick and has a volume that is one fourth of similar foreign products, making it easy to insert into the skull. ”Zhang Lei said that the miniaturization and lightweight of equipment require strong underlying research and development support. Wireless communication and wireless power supply are key factors for the productization of hosts. We will apply the latest wireless technology to the communication of 'Beinao-1' to ensure signal stability, "said Zhang Lei. At the same time, the team will carry out independent research to solve the long-standing problems of wireless power supply being prone to 'disconnection' and strict distance restrictions. We have made some adaptive processing on the power supply module, which can automatically and quickly capture changes in power supply conditions, control power supply, and ensure that the host can work normally under various conditions. ”Zhang Lei said, "Currently, the average effective distance of wireless power supply is 8 millimeters, but our device can wirelessly supply power within a distance of more than ten millimeters and is compatible with everyone's scalp thickness, so it will not be unable to work due to individual patients' thick scalp." To improve safety and smooth interaction with the brain, "electrodes are implanted into the brain. Whether it is the initial dozens of channels or later developed to thousands of channels, half of the electrodes may not work after a few months. ”Luan Guoming, Vice President of Sanbo Brain Hospital at Capital Medical University, introduced that invasive electrode implantation in brain tissue can cause rejection reactions in the human body, and the heat released during electrode operation can also affect brain tissue. These are safety issues that are of great concern in clinical practice. Reducing the side effects of implanted electrodes on the brain is one of the bottlenecks that urgently needs to be overcome in industrial development. At present, the industry provides various solutions, "said Luan Guoming. For example, to address the issue of fever, methods such as millimeter wave wireless power supply and optogenetic manipulation can be used to reduce the generation of energy in the brain. The former directly exchanges energy and information with implanted devices in millimeter wave mode, removing the heat generation process from the brain; The latter implants optogenetic biological devices into the brain, producing only lower heat when interpreting brain signals. At Fujian Sanbo Funeng Brain Hospital, researchers conducted the world's first interventional brain computer interface clinical trial. Through minimally invasive surgery, the stent electrode was transported to the blood vessels around the patient's cerebral motor cortex for EEG signal acquisition, and wireless transmission and power supply equipment were implanted under the patient's skin to achieve wireless communication transmission of EEG signal acquisition and signal transmission, ensuring the safety and effectiveness of the surgery. Luan Guoming explained that fixing the signal acquisition "end" through vascular stents has been widely used in the treatment of other diseases, and this technological path can effectively reduce the safety issues caused by brain implants. We are a joint construction unit of the Beijing Key Laboratory of 'Cross scale Brain Computer Interface Data Research and Transformation' to gather forces and accelerate industrialization implementation. ”Luan Guoming said that to promote the transformation of brain computer interface technology into emerging medical devices, clinical institutions must take the initiative to undertake scientific research tasks from laboratory to clinical implementation, and empower product polishing, iteration, and maturity with clinical practice experience. Relying on its rich clinical resources and expertise in the diagnosis and treatment of neurological diseases, Sanbo Brain Hospital has established a brain computer interface conversion clinical trial platform. By providing clinical trial supply, professional services, and financial support, it promotes the deep integration of scientific research, clinical practice, and industry. Beijing Xinzhida Neurotechnology Co., Ltd., a company incubated by Beijing Institute of Brain Technology and Beijing Institute of Brain Technology, has simultaneously explored the layout and product transformation of two different technological routes, "Beinao-1" and "Beinao-2". The "Beinao-1" has completed 7 patient implantation surgeries in a clinical study initiated by researchers, with a cumulative working time of over 45000 hours in the human body, preliminarily verifying the safety and effectiveness of the product. The 'Beinao No.1' has entered the clinical validation stage, with more than ten centers across the country participating, and patient recruitment has begun. ”Li Yuan, the rotating CEO of Beijing Xinzhida Neurotechnology Co., Ltd., told reporters that as of now, four patients with motor dysfunction caused by spinal cord injury have completed implantation and their postoperative conditions are all good. It is expected to complete clinical trials for about 40 patients this year and submit marketing applications as soon as possible. The 'Beinao-2' is undergoing large-scale animal testing and plans to start clinical research this year. ”Li Yuan said that "Beinao-2" uses flexible microfilament electrodes implanted to read EEG signals, which can provide more accurate "one-to-one" signal reading for single neurons, and can simultaneously read, process, and transmit 512 channels. Clinical trials are a necessary path towards clinical practice and industrialization. In the past two years, more and more forces have been integrated into the industrial research and development of brain computer interfaces. Nowadays, there are more and more doctors who understand brain computer interfaces, and their willingness to participate is also very active. Li Yuan said that this will help gather forces to promote the solid implementation of this future industry. (Looking into the New Era)