You may have heard of the names of GLP-1 drugs, such as semaglutide or tilpotide. They can effectively regulate appetite and help with weight loss (must be used under the guidance of a doctor), and are regarded by many as "miracle drugs for weight loss". However, a confusing phenomenon of "same medicine but different effects" is common: some people experience significant weight loss after taking medication, but the effect is significant; But others have little effect and have to endure side effects such as nausea and vomiting. Is it just a difference in willpower or lifestyle habits behind this? The latest scientific research provides an unexpected perspective: the answer may be hidden in your genes. Recently, a study published in the authoritative journal Nature revealed for the first time two genetic variations closely related to appetite and digestion, which may be associated with different responses to GLP-1 receptor agonists. This study was conducted by scientists from the genetic testing company 23andMe Research Institute. They search for clues related to differences in drug efficacy in the vast ocean of genes in the database like detectives. Ultimately, key genetic variations were identified. The first mutation is located in the GLP-1 receptor gene itself. Its mutation is like an extremely small change in the shape of a 'lock'. Individuals carrying this mutation have a slightly higher average decrease in body mass index after drug use, with an additional weight loss of 0.641%. Although this number may not sound large, it has statistical and biological significance. The second mutation is located in the gene of gastric inhibitory peptide receptor. This mutation has been found to be associated with the risk of nausea and vomiting in patients who use tilpotide, but it does not seem to affect weight loss outcomes. This suggests that the occurrence of side effects has another independent genetic logic, and certain individuals' genes may make them more sensitive to gastrointestinal reactions to drugs. These findings are undoubtedly exciting, as they confirm for the first time in large-scale data that subtle differences in individual genes may be one of the important reasons for the "different effects of the same drug". However, scientists also calmly point out that genes affect the effect, but not the outcome of all stories. Analysis shows that non genetic factors, including gender, age, and which specific medication to choose, remain stronger indicators for predicting weight loss outcomes. Genetic factors are currently considered to have relatively limited influence. But this study suggests that in the future, we may be able to use genetic testing to roughly predict a person's possible reactions and risk of side effects to the "weight loss artifact" before receiving treatment, thereby achieving more personalized and precise obesity treatment. This also tells us that when we make frustrated complaints about why others are effective but I am not, we can reduce our self blame. Your body code is already unique, and science is working hard to decipher the chapters about health in order to find the truly suitable "key" for everyone in the future. (New Society)