The main body of the accelerator device of the IP-SAFE project, which was constructed by the Institute of Modern Physics of the Chinese Academy of Sciences, has successfully completed the closure and installation in Lanzhou New Area a few days ago. IP-SAFE is the world's first alpha medical isotope mass production demonstration device based on superconducting linear accelerator. Its completion will play a key role in breaking China's long-term dependence on imported high-end medical isotopes. The reporter followed in the footsteps of Sun Liangting, a researcher at the Institute of Modern Physics and Executive Deputy Manager of the IP-SAFE project, to explore the unique mysteries of this scientific facility at National Taiwan University. Sun Liangting introduced that in the field of advanced radiotherapy, targeted alpha (α) therapy isotopes and their drugs have the characteristics of safety, precision, and effectiveness in the treatment of cancer, and are a research hotspot in the field of radionuclide therapy. Europe and America have entered the stage of clinical application research, but due to the constraints of complex processes and low production, they are currently in a rare shortage of drugs worldwide and cannot meet the large-scale clinical demand. China's targeted alpha therapy isotopes mainly rely on imports and have long faced problems of short supply and interruption. Sun Liangting told reporters that the project research team has mastered and broken through the key technology of continuous wave superconducting ion linear accelerator, independently designed, developed and verified core technologies such as high-power isotope reaction targets and isotope chemical separation. Based on this, they innovatively proposed a large-scale production technology route for alpha isotopes based on strong current acceleration, and laid out the construction of the "Precision Radiotherapy Alpha Isotope Drug Development Platform (IP-SAFE) based on a hundred kilowatts proton superconducting linear accelerator" in Lanzhou New Area. What is the difference between this cancer treatment technique and the "heavy ion cancer treatment" technique developed by modern physics? Sun Liangting introduced that heavy ion therapy for cancer is the use of high-energy heavy ions generated by acceleration to act on the lesion, and the effect is relatively good for solid tumors. Alpha emitting isotope drug therapy utilizes the high linear energy transfer and short range advantages of alpha isotopes to kill cancer cells through targeted targeted targeted clearance, which is more effective for diffuse and postoperative diffuse tumors. The IP-SAFE project is a product of the combination of long-term basic research and advanced technology research in modern physics, and is also another important progress in promoting the transformation of large scientific device achievements and serving people's life and health. ”The person in charge of the Institute of Modern Physics said that after the project is fully completed, it will effectively enhance the level of nuclear medicine diagnosis and treatment in China, injecting new impetus into the development of China's biopharmaceutical industry. (New Society)