Optimizing the layout of major productive forces is not only a major deployment for the development of the national economy, but also a key means to promote efficient allocation of resources and achieve regional coordinated development. The Proposal of the Central Committee of the Communist Party of China on Formulating the 15th Five Year Plan for National Economic and Social Development, which was reviewed and approved at the Fourth Plenary Session of the 20th Central Committee of the Communist Party of China, proposes to leverage the combined effects of regional coordinated development strategy, regional major strategy, main functional zone strategy, and new urbanization strategy, optimize the layout of major productive forces, give full play to the role of key regions as growth poles, and build a regional economic layout and territorial spatial system with complementary advantages and high-quality development. This is a major decision and deployment made by the Central Committee of the Communist Party of China to coordinate the overall strategy of the great rejuvenation of the Chinese nation and calmly respond to the unprecedented changes in the world. It is a key measure to promote high-quality development and has profound significance for building a new development pattern, safeguarding national security, and promoting regional coordinated development. At present, standing at the historical node of the "15th Five Year Plan" layout, it is of great practical significance to systematically sort out the spatial response of major productivity layouts to the overlapping effects of multiple regional strategies, and scientifically plan future optimization paths. 1、 In recent years, the regional strategic synergy effect of China's major productive forces layout has been achieved through the coordinated development strategy of regions, major regional strategies, and the strategic synergy and empowerment of main functional zones. The spatial pattern of China's productive forces has been systematically reconstructed, and a strategic support system with clear levels and coordinated division of labor has been constructed. The regional coordinated development strategy focuses on the balanced development of the four major sectors of "coordination", with major regional strategies emphasizing the "stimulation" of five key regional economic drivers, and the main functional zone strategy focusing on "adaptation" to the development orientation of county-level units. The multi-level spatial coordination pattern of "region city cluster county" is becoming increasingly perfect, laying a solid foundation for building a regional economic layout and national spatial system with complementary advantages and high-quality development. （1） The regional coordinated development strategy aims to create a basic pattern of "clear division of labor and complementary advantages". The regional coordinated development strategy guides each region to find its own positioning, highlight the integration of regional and local advantages, unleash regional development vitality, and create an industrial dislocation layout that "holds hands and forms a joint force". Based on resource endowment and industrial foundation, the western region focuses on developing characteristic advantageous industries such as clean energy, characteristic agriculture and animal husbandry, cultural tourism, etc., building a strong national ecological security barrier, and continuously transforming the "high aesthetic value" of ecology into "high value" for development. The Northeast region has a complete range of industrial categories and a solid foundation. With digital transformation and green transformation as the starting point, it promotes the revitalization and upgrading of traditional advantageous industries such as equipment manufacturing and raw materials, focuses on solving development difficulties, enhancing development resilience and endogenous power. The central region relies on its geographical advantage of "connecting the south and north, connecting the east and opening up the west", orderly undertakes the transfer of industries from the east, cultivates and strengthens advanced manufacturing clusters, builds an important national grain production base and modern comprehensive transportation hub, and accelerates its rise from a "depression" of opening up to the outside world to an inland "highland" of opening up. The eastern region fully leverages the advantage of highly concentrated innovation factors, bravely takes on the "backbone" in strategic emerging industries and future industrial layouts, and takes the lead in becoming an important battlefield for developing new quality productive forces, leading the country's high-quality development. （2） Constructing a development pattern of "core leadership and hierarchical promotion" for major regional strategies. Regional major strategies strengthen the development of strategic key areas, promote integrated development between regions, and play a demonstrative and radiating role in optimizing the spatial layout of productivity and promoting coordinated regional development. The coordinated development of Beijing Tianjin Hebei region adheres to a problem oriented approach, firmly and orderly promotes the relocation of non capital functions in Beijing, deepens the industrial cooperation model of "Beijing Tianjin R&D and Hebei transformation", promotes the integration of innovation chains and ecological governance among the three regions, and jointly cultivates world-class industrial clusters. The construction of the Guangdong Hong Kong Macao Greater Bay Area is based on high-level opening up, focusing on promoting the connection of rules and mechanisms, and creating a world-class economic platform and international science and technology innovation center under the "One Country, Two Systems" policy, where factors flow freely, innovation vitality bursts, and diverse cultures are integrated. The integrated development of the Yangtze River Delta will strengthen its leading role, concentrate on building a modern industrial system with global competitiveness in integrated circuits, biomedicine, artificial intelligence, and other fields, consolidate and enhance its strong and active growth pole functions, and steadily promote institutional opening up. The development of the Yangtze River Economic Belt and the ecological protection and high-quality development of the Yellow River Basin adhere to ecological priority and green development, establish and improve a long-term mechanism for coordinated protection and governance of the entire basin, promote the green transformation and upgrading of upstream, midstream and downstream industries, and focus on building an important ecological economic axis belt. （3） Constructing a governance pattern of "resource intensive and bottom line constraint" for the main functional area strategy. The main functional area strategy focuses on implementing tailored development and providing direction for the layout of major productive forces, that is, seeking coordinated development on the basis of green development. The main functional area strategy requires differentiated development. The scientific delineation and rigid control of the "three zones and three lines" have clarified the "hard constraints" on the carrying capacity of resources and environment, and set an insurmountable "ceiling" for national development. The main functional area strategy promotes collaborative development. As the top-level design for the modernization of national spatial governance, the main functional area strategy provides a blueprint for coordinated development and protection with a systematic thinking of "the whole country playing a chess game". This map is not only a "planning map" for improving food security and ecological security, but also a "roadmap" for optimizing the layout of major productive forces and spatial implementation. The main functional area strategy supports high-quality development. Under the constraints of national spatial planning, the protection of arable land has undergone a historic transformation from "reducing in the south and increasing in the north" to "increasing in both the north and south". The urban development model has accelerated from external expansion to internal improvement, and the efficiency and sustainability of national spatial utilization have been significantly enhanced. 2、 The optimization measures for the layout of major productive forces during the "15th Five Year Plan" period are aimed at the "15th Five Year Plan", and need to focus on key areas based on the overlapping effects of multiple regional strategies, in order to optimize the layout of major productive forces with more forward-looking and systematic measures. In the face of new changes, trends, and challenges in the domestic and international development environment, it is necessary to adhere to the construction of a highly coordinated regional development mechanism for "people, industry, and cities", focusing on three precise paths: first, to cultivate momentum, by building a highland of new quality productivity, expanding high-level open space, and creating a new engine for regional growth; The second is resilience, by strengthening the national strategic hinterland backup system, enhancing the construction of a strong maritime economy, and weaving a dense regional economic security network; The third is smooth circulation, by breaking down regional cooperation barriers, deepening the construction of a unified national market, releasing the efficiency of coordinated development system, and responding to various uncertain challenges with the certainty of high-quality development. （1） Strengthen the construction of national strategic hinterland, enhance regional development resilience and security. Strengthening the construction of the national strategic hinterland is a major decision made in response to changes in the international and domestic situation, and plays a stabilizing role in optimizing the layout of major productive forces. It is worth noting that the construction of national strategic hinterland cannot be equated with the "New Third Line Construction", as their backgrounds, purposes, and layouts are completely different. The national strategic hinterland is the strategic depth for effectively addressing risks and challenges. Scientific layout of strategic industries and key infrastructure related to energy security, food security, industrial chain security, and national defense security in deep regions such as the central and western regions, leaving greater room for maneuver, is an inevitable choice to calmly respond to the accelerated evolution of the world's century long changes. The national strategic hinterland is a strategic arrangement that serves the great cause of national rejuvenation. The national strategic hinterland is not only an important link in the domestic circulation, but also a key point in the international circulation. Strengthening its construction is an inherent requirement for accelerating the construction of a new development pattern with the domestic circulation as the mainstay and the domestic and international circulations mutually promoting each other. The national strategic hinterland is a key support for promoting regional coordinated development. The construction of national strategic hinterland needs to be deeply integrated with regional coordinated development strategies and major regional strategies, forming a spatial integration pattern of core leading areas and strategic depth areas working together and singing in harmony, injecting new momentum into the construction of an economic powerhouse. （2） Systematically plan the layout of emerging industries and develop new quality productivity according to local conditions. Developing new quality productive forces is an inherent requirement and key support for promoting high-quality development, and plays a "multiplier" role in the layout of productive forces. It should be pointed out that the development of new quality productivity cannot be achieved through mass competition or homogeneous competition. Regions that lay out new quality productivity must have certain geographical conditions and follow the basic principle of "developing new quality productivity according to local conditions". Strengthen the leading role of developed regions. Support developed regions such as the eastern coastal areas to take the lead in breakthroughs in cutting-edge technologies and future industries such as artificial intelligence, quantum information, and life sciences, to create a new source of high-quality productivity, and to strengthen innovation radiation and industrial drive throughout the country. Inspire new vitality in old industrial bases. Promote the use of new technologies to empower the transformation and upgrading of traditional industries in old industrial bases in Northeast and Central Western China, while actively cultivating local characteristic emerging industry clusters, achieving the simultaneous development of "old trees developing new branches" and "new trees rooting deep roots". Adhere to national coordination and regional synergy. Strengthen the guidance of the national level on the layout of emerging industries, clarify regional division of labor, avoid following the trend and redundant construction, and form a new quality productivity development map that is tailored to local conditions, complementary in advantages, and coordinated in the chain. （3） Comprehensively optimize the layout of regional openness and shift from single point breakthroughs to system integration. Optimizing the layout of regional openness is an active plan to respond to changes in the international economic cooperation situation, and plays a "booster" role in the layout of productivity. The new pattern of all-round opening up of "land sea linkage and east-west mutual assistance" needs to be promoted in a coordinated manner according to "points, lines, and surfaces". Breakthrough through points and create a high-level open platform. Deepen the reform and innovation of the pilot free trade zone (Hong Kong), expand the institutional opening pilot, support the pilot free trade zones in the central and western regions to explore the path of differentiation, strengthen the economic and trade cooperation with the "the Belt and Road" countries, and improve the level of inland opening. Strengthen the international logistics channel by gathering energy through lines. Optimize and upgrade the operational networks of China Europe freight trains and the Western Land Sea New Corridor, enhance the collection and distribution capacity of hub nodes, build a "freight train+industry" model, ensure smooth international circulation of industrial and supply chains, and promote the coordinated development of economic and trade industrial belts along the route. Building a new system of global openness through surface radiation. Deepen innovation cooperation with relevant countries in high-end manufacturing, digital technology and other fields towards the east; Expand energy and resource security and modern agricultural cooperation with relevant countries to the north; Strengthening infrastructure connectivity and green capacity cooperation with Central Asian and Central and Eastern European countries to the west; Deeply integrate into the RCEP (Regional Comprehensive Economic Partnership) regional industrial chain and supply chain network towards the south, and accelerate the formation of a new open system led by institutional openness and coordinated resources across the region. （4） Deepen all-round cooperation between the East, West, and Central regions, and promote the construction of a unified national market. Deepening the construction of a unified national market is an important lever for handling the relationship between the government and the market, and plays a "catalyst" role in the layout of productivity. Strengthen regional coordination, integration, and internal integration. Combining the "cage for bird exchange" in the eastern region with the "nest building and phoenix attraction" in the central, western, and northeastern regions to build a cross regional collaborative innovation system. Break down administrative barriers and promote the unified connection of infrastructure, rules, standards, and policies within the region, and achieve division of labor and cooperation on a larger scale. Building a modern infrastructure system. Vigorously promote the digital transformation of traditional infrastructure and moderately advance the layout of new infrastructure. Give full play to the driving role of new quality productivity, overcome spatial distance barriers through the widespread application of new technologies such as digitization, networking, and intelligence, improve the high standard connectivity level of market facilities, and gradually eliminate factors