According to Beihang University, Professor Chang Lingqian's team from the School of Medical Science and Engineering and Professor Xu Ye's team from the School of Mechanical Engineering and Automation have jointly developed a flexible implantable bioelectronic device POCKET with Peking University First Hospital, Chinese Academy of Medical Sciences Cancer Hospital, City University of Hong Kong, University of Illinois, and other institutions. This device can be personalized and perfectly adhered to the surface of complex shaped organs, and achieves safe, efficient, and accurate whole organ drug delivery or gene transfection through nanoelectroporation effect. The relevant results were published in the international journal Cell. According to the research team, this work began with a clinical problem that left doctors feeling powerless: for patients with hereditary ovarian gene mutations, clinical guidelines generally recommend removing both ovaries and fallopian tubes, but this means permanent loss of fertility. The existing gene therapy technologies, such as viral vectors, are difficult to apply to sensitive organs such as the ovaries due to the potential risk of integration into the germ cell genome and interference with the human gene pool. In response to this issue, the research team turned their attention to the physical method of electroporation, which involves applying an electric field to the cell membrane to instantly open it. However, the surface of the ovary is rough and uneven, with numerous grooves and fissures. Traditional electroporation devices cannot achieve "high conformal adhesion" to the surface of the organ, resulting in poor controllability and low efficiency of drug delivery. The team drew inspiration from the traditional Paper Cuttings art and creatively put forward the "organ customization Paper Cuttings conformal theory". This theory establishes for the first time the quantitative relationship between the geometric parameters of Paper Cuttings structure (such as unit size, hinge width) and organ curvature, material properties, conducts three-dimensional scanning for organs, and intelligently generates the most suitable size, so as to guide the design of Paper Cuttings patches that can be completely conformal and retain the maximum functional area on specific curvature organs. The 4-layer functional design of POCKET can achieve a highly conformal and large-area adhesion like an "electronic coat" on the surfaces of various organs of different species. The research team stated that they have validated the powerful function of POCKET in various animal models and ex vivo human tissues. The POCKET platform provides a new tool for precise treatment of diseases such as ovarian cancer prevention and organ damage repair, and can be extended to the treatment, regeneration, repair, and functional regulation of various internal organs such as the liver, heart, and lungs, opening up a new paradigm for the future development of bioelectronics medicine. It is reported that high-tech industrialization companies incubated based on this technology have completed multiple rounds of financing. The first conversion product - "Ultra NEP Ultra Penetrating Device" has been applied in fields such as skin health. In the future, the team will further expand its applications in the field of medical grade equipment. (New Society)