On the 17th, it was learned from Lanzhou University that the research team of natural medicinal chemistry biology in the School of Pharmacy of the university has made important breakthroughs in the field of alkaloid antibacterial mechanism research. Researchers have successfully screened a candidate drug Z24 with excellent antibacterial activity and revealed a novel antibacterial mechanism of a new derivative of Baiyeteng alkaloid. The relevant research results were recently published in the international academic journal Science Progress. In the study, the team used natural source alkaloids of the new white wisteria alkaloid as the lead and screened them through diversity oriented synthesis and molecular structure optimization strategies. In the end, the team obtained the new derivative Z24 of Baiyeteng alkaloid and systematically studied its mechanism of action using modern biological analysis methods such as chemical biology, proteomics, and transcriptomics. Research has shown that the derivative Z24 of the new white leaf vine alkaloid is a candidate drug with excellent antibacterial activity The main member of the team, Professor Liu Yingqian from the School of Pharmacy at Lanzhou University, introduced that Z24 can specifically bind to and inhibit the synthesis of thiamine synthase (Bcthi4) in Botrytis cinerea, block the synthesis of thiamine in the fungal body, and exhibit excellent inhibitory activity against Botrytis cinerea, as well as broad-spectrum inhibitory effects on multiple important pathogenic fungi. Compared with traditional agricultural antibiotics, this new antibacterial mechanism has significant advantages. Due to the absence of the Bcthi4 pathway in mammalian and plant cells, Z24 selectively inhibits the growth of pathogenic fungi, avoiding potential toxicity to crops and mammals. This unique mode of action and mechanism make Z24 have better biosafety, while avoiding or reducing the risks of environmental pollution and fungal resistance, "said Liu Yingqian. This study not only reveals a novel antibacterial mechanism of the new Baiyeteng alkaloid derivative, but also provides theoretical basis and technical support for further biologically rational design and creation of new antibacterial drugs targeting thiamine thiazole synthase. (New Society)